Fig. 6: Knockdown of YTHDF2 suppresses tumor growth in MM xenograft models. | Oncogene

Fig. 6: Knockdown of YTHDF2 suppresses tumor growth in MM xenograft models.

From: N6-methyladenosine reader YTHDF2 promotes multiple myeloma cell proliferation through EGR1/p21cip1/waf1/CDK2-Cyclin E1 axis-mediated cell cycle transition

Fig. 6

A RPMI-8226 cells transfected with shNC or shYTHDF2 were injected in the left or right flanks of BALB/c nude mice (n = 4). B Mice were sacrificed when tumor diameter was more than 15 mm, xenograft tumors were completely dissected. C Tumor volume was recorded every 3 days and calculated by the formula: (width2 × length ×0.5). (D) Tumor weight was recorded after dissection. E Representative hematoxylin-eosin (H&E) staining. F Representative IHC staining of YTHDF2, EGR1, p21cip1/waf1, CDK2, Cyclin E1 and Ki-67 in tumors from negative control and YTHDF2-downregulated nude mice. Data are mean ± SD values. *P < 0.05.

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