Fig. 6: GPx2 knockdown promoted KYNU-mediated kyn metabolism by increasing ROS levels. | Oncogene

Fig. 6: GPx2 knockdown promoted KYNU-mediated kyn metabolism by increasing ROS levels.

From: Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism

Fig. 6

A, B Flow cytometry assays following GPx2 knockdown or treatment with H2O2 (0.01, 0.05, 0.1, 0.5, and 1.0 mM) for 30 min. C, D Quantitation of the flow cytometry assay data. E GPx2, KYNU, and AhR expression was detected by Western blotting after treatment with H2O2 (0.01, 0.05, 0.1, 0.5, and 1.0 mM) for 30 min in GC cell lines. F GPx2 and KYNU expression was detected by Western blotting after treatment with NAC (20 mM) for 1 h in GC cell lines or GPx2 knockdown GC cell lines. *P < 0.05, **P < 0.01.

Back to article page