Fig. 7: GPx2 knockdown suppressed GC proliferation in gastric xenograft tumor models.

A GC cells stably transfected with GPx2 shRNA or empty vector were subcutaneously inoculated into nude mice. The mice were randomly divided into the control, shGPx2#1, and shGPx2#2 groups as described in the Methods. B The tumor sizes were determined using Vernier calipers. Tumor growth curves were generated based on the tumor volumes measured in the mice. C The tumor weights were determined at the end of the experiments. D The body weights of nude mice were determined every five days. E E-cadherin, N-cadherin, Vimentin, KYNU and AhR were detected by IHC (scale bar, 100 μm). *P < 0.05, **P < 0.01.