Fig. 7: Levels of FBXO28, PKAα, p-CREB and SNAI2 in HCC specimens, and clinical significance of PRKACA.
From: FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation
A Protein levels of FBXO28, PKAα, p-CREB and SNAI2 in paired HCC specimens by IB analyses. Arrows indicate target band. B Quantification data of (A) were expressed as mean ± SD (n = 8). *P < 0.05, **P < 0.01 and ***P < 0.001 (paired T-test). C Expression of PRKACA mRNA levels in HCC and normal cohorts in TCGA dataset. **P < 0.01 (independent T-test). D Correlation of PRKACA expression and overall survival (OS) via Kaplan–Meier survival analysis of liver cancer patients. E Working model for the regulatory function of FBXO28 during HCC EMT process by degrading SNAI2 via UPS.
