Fig. 2: Differentially expressed genes in matched extremity tumors and lung metastases. | Oncogene

Fig. 2: Differentially expressed genes in matched extremity tumors and lung metastases.

From: RNA-sequencing predicts a role of androgen receptor and aldehyde dehydrogenase 1A1 in osteosarcoma lung metastases

Fig. 2

A The heatmap demonstrates that LM, below the red bar, exhibit defined clusters of upregulated genes. 316 genes were differentially expressed (FDR-adjusted P < 0.01), fold-change = 1.5, and TPM expression profiles in the tenth percentile. B Principal component analyses also demonstrated distinct clustering of LM samples (blue) and extremity tumor samples (red). Analyses performed with paired samples, which included only patient-matched extremity tumors vs. lung metastases (n = 4 sample sets).

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