Fig. 3: Inhibiting FOXK2 expression suppresses the cell proliferation and migration in OC. | Oncogene

Fig. 3: Inhibiting FOXK2 expression suppresses the cell proliferation and migration in OC.

From: Phosphorylation of FOXK2 at Thr13 and Ser30 by PDK2 sustains glycolysis through a positive feedback manner in ovarian cancer

Fig. 3

A, B Validation of FOXK2 interference efficiency at protein and mRNA levels in OVCAR8 and ES-2 cells. C, D A CCK-8 assay was conducted using NC or si-FOXK2 in OVCAR8 and ES-2 cells. E Subcutaneous xenografts transplanted with OVCAR8 cells expressing shNC and shFOXK2 (n = 5). Left: tumor growth curve in vivo. Middle: tumor growth curve in vivo. Right: Tumor weight and volume. F Cellular migration ability was detected by transwell migration in OVCAR8 and ES- 2 cells expressing shNC or siFOXK2. Left: representative pictures; Right: the number of migrated cells. Data are presented as the means ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001, ****P < 0.0001.

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