Fig. 2: High-Fat Diet (HFD) supplementation promotes adipose tissue accumulation and induces endometrial hyperplasia. | Oncogene

Fig. 2: High-Fat Diet (HFD) supplementation promotes adipose tissue accumulation and induces endometrial hyperplasia.

From: Obesity-induced extracellular vesicles proteins drive the endometrial cancer pathogenesis: therapeutic potential of HO-3867 and Metformin

Fig. 2

A, B Immunocompetent mice were treated with a high-fat diet (HFD, 45% protein calorie) for 24 weeks. Representative images depict accumulated levels of adipose tissue (circled) in mice fed with a HFD for 24 weeks. Changes in body weight were assessed at the beginning (8 weeks) and end (24 weeks) of the HFD treatment (n = 10/group, p < 0.01). C Increased accumulation of adipose tissue was observed in mice fed with a HFD compared to controls (n = 5, p < 0.005). D, E Increased uterine enlargement and weight were observed in mice fed with a HFD compared to controls (n = 5, p < 0.005). F Enhanced cell proliferation in the endometrium of mice fed a HFD compared to controls (normal diet) is illustrated by hematoxylin-Eosin (H&E) staining. The inset shows a higher magnification of the increased cell proliferation.

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