Fig. 6: High expression of CRC (ELF3/EHF/TGIF1-High) were associated with poor prognosis on patients with LUAD. | Oncogenesis

Fig. 6: High expression of CRC (ELF3/EHF/TGIF1-High) were associated with poor prognosis on patients with LUAD.

From: Aberrant super-enhancer landscape reveals core transcriptional regulatory circuitry in lung adenocarcinoma

Fig. 6

A qRT-PCR analysis of ELF3, EHF, and TGIF1 among 20 pairs of matched lung adenocarcinoma and adjacent normal tissue. B Correlation analyses conducted between the mRNA expression of ELF3, EHF, and TGIF1 from (A). C ELF3, EHF, and TGIF1 were detected in peritumoral tissue and representative LUAD samples by immunohistochemistry staining. Scale bar, 100 μm. D Kaplan–Meier analysis of overall survival of LUAD patients (TCGA-LUAD) with low (low expression of ELF3, EHF, and TGIF1, n = 78) and high (high expression of ELF3, EHF, and TGIF1, n = 52) ELF3/EHF/TGIF1 expression (log-rank test, two-sided). E Left panel: a schematic diagram showing the key targets and small-molecule inhibitors of SE. JQ1 and OTX015 targeting BRD4, THZ1 targeting CDK7; CBPC30 targeting EP300. Right panel: CRCs are assembled as fully interconnected loops of auto-regulated TFs. Schematic graph of the model of interconnected circuitry, with hexagons representing enhancer elements and proteins, respectively. Data in (A) were mean ± SD; n = 3 independent experiments, two-tailed paired Student’s t test, ns not significant, *p < 0.05; **p < 0.01; ***p < 0.001 (B) R, Pearson correlation coefficients (r) and p values.

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