Fig. 4: The cyclin D1 carboxyl-terminal ___domain has intrinsic disorder tendency. | Oncogenesis

Fig. 4: The cyclin D1 carboxyl-terminal ___domain has intrinsic disorder tendency.

From: A cyclin D1 intrinsically disordered ___domain accesses modified histone motifs to govern gene transcription

Fig. 4

A Disorder tendency and disordered binding site prediction. PRDos (blue), IUPred long (maroon), PONDR (orange) predictions show that the carboxy-terminal 40 residues (aa 256 - aa295) have a strong tendency to be intrinsically disordered, whereas ANCHOR (black) suggests that last 15 amino acids contain a protein-protein interaction site. B Multiple sequence alignment of the last (carboxyl-terminal) 100 amino acids of cyclin D1 from various species and of human cyclin A1, B1 and E1. The E-box motif was found in 148 human proteins by BLASTP, and their enrichment (C) and ratio (D) in GO Biological Process (BP) categories (“regulation of…”, no. of hits in the given category/148 polyE proteins) is shown.

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