Table 3 Adiposity and body composition indicators at age 4 years by infancy (0–2 years) weight growth trajectory in LGA and AGA children.

From: Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood

Infancy growth trajectory

 

Low growth (1)

Mid growth (2)

High growth (3)

Adjusted Pa

β (95% CI)

1 vs. 2

3 vs. 2

BMI (kg/m2)

AGA

14.4 ± 3.2

15.0 ± 2.1

16.3 ± 2.4

<0.0001

−0.61 (−1.04, −0.18)

1.06 (0.47, 1.65)

LGA

15.0 ± 1.5

15.8 ± 2.1

17.2 ± 2.4

0.002

−0.97 (−1.99, 0.05)

1.05 (−0.10, 2.19)

BMI z score

AGA

−0.9 ± 1.5

−0.3 ± 1.4

0.6 ± 1.5

<0.0001

−0.50 (−0.82, −0.18)

0.75 (0.35, 1.15)

LGA

−0.6 ± 1.3

0.2 ± 1.4

1.2 ± 1.4

0.002

−0.70 (−1.42, 0.04)

0.78 (0.02, 1.54)

PBF (%)

AGA

11.4 ± 8.6

14.1 ± 7.8

18.0 ± 7.6

<0.0001

−2.39 (−4.15, −0.62)

3.29 (1.51, 5.07)

LGA

14.0 ± 6.5

16.7 ± 8.6

20.8 ± 9.6

0.002

−2.89 (−6.80, 1.03)

4.58 (0.25, 8.91)

BFM (kg)

AGA

2.0 ± 2.1

2.6 ± 1.7

3.8 ± 2.1

<0.0001

−0.59 (−0.94, −0.23)

1.02 (0.58, 1.45)

LGA

2.6 ± 1.7

3.3 ± 2.1

4.9 ± 2.9

0.0003

−0.92 (−1.85, 0.01)

1.31 (0.19, 2.43)

FFM (kg)

AGA

14.1 ± 1.7

15.1 ± 1.8

16.5 ± 1.9

<0.0001

−1.10 (−1.39, −0.80)

1.16 (0.74, 1.59)

LGA

14.8 ± 1.7

15.9 ± 1.9

17.6 ± 2.0

<0.0001

−1.52 (−2.31, −0.73)

1.26 (0.37, 2.15)

  1. Data presented are mean ± SD or n (%), or the change (β) in the outcome (e.g., PBF) comparing the high- or low- to mid-growth (reference) trajectory from generalized linear models. Tests for interaction between growth trajectory and LGA/AGA status: P = 0.0005 for BMI, P = 0.02 for BMI z score, P < 0.0001 for BFM, P = 0.08 for PBF, P < 0.0001 for FFM.
  2. BMI body mass index, PBF percent body fat, FFM fat free mass, BFM body fat mass, LGA large-for-gestational age (birth weight >90th percentile), AGA appropriate-for-gestational age (birth weight 10th–90th percentiles).
  3. aP values for comparisons among the three groups adjusted for maternal (pre-pregnancy BMI, education, alcohol in pregnancy, gestational diabetes mellitus) and infant (cesarean section, sex, gestational age, breast feeding) characteristics; other co-variables did not affect the comparisons.
  4. P values and regression coefficients in bold: P < 0.05.