Fig. 5
From: Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells
NOX5 promotes ESCC progression in vitro. a, b NOX5-overexpressing KYSE30 (a) or KYSE410 (b) cells were treated with 100 nM dasatinib, 1 μM PP2 or control solvent, or scramble control or NOX5-silenced KYSE30 or KYSE410 cells were cultured under normoxic and hypoxic conditions for 3 days. The cell growth was measured by MTS assay. c, d above cells were cultured under normoxic and hypoxic conditions for 24 h. The tumor invasion was evaluated by Transwell invasion assay. *P < 0.05; **P < 0.01; ***P < 0.001; two-tailed unpaired Student’s t-test. Error bars represent mean ± SD of three or five independent experiments
