Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis

Fig. 4

Steric conflicts between W19 and W27 in ACE2 when engaging SARS-CoV-2 S-RBD. The S-RBD/ACE2[W19/Y330] (S-RBD in green and ACE2 in cyan) and S-RBD/ACE2[W27/Y330] (S-RBD in light yellow and ACE2 in magenta) complex structures solved in this study are superimposed onto each other and presented in the left panel. A magnified view of the S-RBD/ACE2-binding interface is highlighted in the right panel. The interface-located residues W19, W27, and Y330 are shown and labeled

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