Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice

Fig. 1

The expression of CB6 mAb using the replicable VEEV replicon as vector. a Schematic of the replicable VEEV replicon expressing the heavy (H) and light (L) chains of a human neutralizing anti-SARS-CoV-2 monoclonal antibody CB6. b BHK-21 cells were transfected with 5 μg VEEV-rep-CB6 mRNA, and the transfected cells were fixed and stained for the expression of CB6 mAb (red) and VEEV-nsP1 (green) using Alexa FluorTM 568 conjugated goat anti-human IgG (H + L) and anti-VEEV nsP1 mouse serum, respectively, at 24 and 48 h post-transfection (hpt). Nuclei were stained with DAPI (blue). Scale bars represent 50 μm

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