Fig. 5
From: Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice
Inactivated SARS-CoV-2 induces an adaptive immune response in hACE2 mice. a Flow cytometric analysis of subsets of effector (labeled as CD44+ and CD62L-) and central (labeled as CD44+ and CD62L+) memory T cells from inguinal lymph nodes in mice on 14 dpi. b, c Flow cytometric analysis on the secretion of IFN-γ (b) and IL-4 (c) in T cells from spleens on 14 dpi when stimulated with recombinant S1 protein. d, e Detection of IgG and IgM antibodies titers in sera against the S1 protein of SARS-CoV-2 on 7 dpi (d) and 14 dpi (e). f Detection of pseudovirus neutralization activity of the sera on 14 dpi. Data represent the mean ± SEM. Significance is indicated by: ns, no significance; *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001
