Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events

Fig. 3

Phylogenetic network and scanning of the spike gene from representative Omicron subvariant sequences. a Representative Omicron spike protein haplotypes (each consisting of at least 50 sequences) were constructed with PopART using the median-joining method. Nucleotide changes were notated with lines. The spike gene from Wuhan-Hu-1 strain was set as the root. The number of sequences in each haplotype were modified into different orders of magnitude, and subgroups based on the mutation types were delineated by color. b BootScan analysis of revertant and representative haplotypes of Omicron spike gene. Representative spike Omicron haplotypes (H3, H4, H7) sequences and selected reversion haplotypes (H18, H39, H44) sequences are included. Bootscan map was constructed by Simplot 3.5.1 (https://sray.med.som.jhmi.edu/SCRoftware/SimPlot/) using neighboring-joining method with 100 bootstrap replicates. Wuhan-Hu-1 spike sequences were set as references and reversion region was annotated. c Overview of possible evolution mechanism of reversion haplotypes and haplotypes with mutations from Delta and other variants

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