Fig. 5
From: Methylation across the central dogma in health and diseases: new therapeutic strategies
Methylation remodeling of non-tumor cells in the tumor microenvironment (TME). The TME is populated by various cell types including immune cells (e.g., T lymphocytes, natural killer cells, macrophages, neutrophils, and dendritic cells), stromal cells (e.g., fibroblasts and mesenchymal stromal cells), and blood and lymphatic vessels. To support tumor development and immune evasion, tumor cells induce alterations of the methylome landscape and subsequent gene expression changes in these TME cells. Examples of methylation remodeling of chromatin, mRNAs, and nonhistone proteins (represented by cartoons in the figure) are summarized
