Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block “eat-me” signal

Fig. 2

A20 inhibited anti-tumor immune response in vitro. a The flow cytometry analysis of HLA-A2. b The lymphocytoxicity effect of PBMCs on THC8307 cells when A20 expression was manipulated by overexpression (OE) or short hairpin silencing (sh). c The ELISA analysis of T cell activation-related cytokines from the co-culture medium of THC8307 cells and PBMCs, n = 3. d, e The effect of A20 expression on lymphocytoxicity and cytokine release from the co-culture medium of CaCO2 cells and PBMCs, n = 3. f–i The effect of PD-1 inhibitor on lymphocytoxicity and cytokine release from the co-culture medium of A20-knockdown CRC cells and PBMCs, n = 3. All experiments were performed in triplicate. Data was represented as the mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; n.s not significant

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