Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

Fig. 1

Decline in NAD+ level from PBMCs associated with vascular function was restored by NMN supplement in hypertension. a NAD+ and its metabolites levels in PBMCs were detected by HPLC-MS in hypertensive patients (n = 50) and healthy subjects (n = 52). b, c NAD+ level in PBMCs were correlated with SBP (b) and DBP (c). d, e NAD+ level in PBMCs were correlated with FMD (d) and baPWV (e). f–j Changes NMN level (f), NAD+ level (g), systolic blood pressure (h), diastolic blood pressure (i), FMD (j), and baPWV (k) from baseline to the end of treatment (Life modification [LM] group: n = 10; NMN supplement group: n = 9). *p < 0.05, ***p < 0.001

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