Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis

Fig. 1

Primidone treatment mitigates ALS-like disease development in SOD1G93A mice. a The effect of primidone dosing (primidone or vehicle treated from 10 weeks of age) on the onset of motor dysfunction in SOD1G93A mice. b All mice were weighed once a week from 10 weeks to 19 weeks of age. NTG: non-transgenic mice. c All mice were tested mobility in open field test from 13 weeks to 20 weeks of age. Statistical analysis of onset was conducted with Log-rank (Mantel-Cox) test, ***P < 0.001. Data are expressed as mean ± SD, n = 10 mice/group, ***P < 0.001, ****P < 0.0001

Back to article page