Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis

Fig. 2

Primidone suppresses RIPK1 activation and ameliorates axonal pathology in the spinal cords of SOD1G93A mice. a Electron microscopic images of the motor axon myelination in the lumbar spinal cords of non-transgenic mice (NTG) and SOD1G93A transgenic mice (14 weeks old) with or without primidone treatment. Scale bars, 5.0 μm. The mean g-ratios (b), individual g-ratios distribution (c) and the distributions of axonal diameters (d) in the lumbar spinal cord (L1-L4) of NTG and SOD1G93A transgenic mice with or without primidone treatment. e The spinal cord samples were analyzed by immunostaining for p-S166 RIPK1, or DAPI for nuclei (n = 3). Scale bars, 40 μm. f Cells with activated RIPK1 were quantified by ImageJ. Statistical analysis of g-ratios and cells with activated RIPK1 was conducted with unpaired t-test, Brown-Forsythe and Welch ANOVA test. Data are expressed as mean ± SD, n = 3 mice/group, ***P < 0.001

Back to article page