Fig. 1

Summary table and risk factor analysis of the study. a Two hundred and seventy EBNA-1 seropositive MS patients and 270 matched EBV-seropositive healthy control according to sex, age, time since EBV seroconversion and occurrence of IM were recruited. While EBNA^high healthy controls were found with equally high levels of EBNA1-GlialCAM cross-reactive antibody, NK cells and EBV-specific CD8⁺ T cells were identified as critical in MS occurrence, and multiple virus and host genetics factors were discovered influencing NK and T cell function. b After statistical analysis, weak NKG2C response as an individual factor and EBV LMP1 variant with HLA-E*0101 as a multiple factor group were found highly associated with increased MS risk by 41-fold and 261-fold. The summary table is colored to identify different subject groups. The original data of risk factor analysis came from the reported research article and mean odds ratios for each factor or factor combination group were marked beside with red text indicating the largest value in each chart. The icon ↑↓ indicated the high or low factor level and the icon + and − indicated the positive or negative factor level