Fig. 1
From: The multiple roles of interferon regulatory factor family in health and disease
The genes and proteins structures of IRF family members. a The genomic structures. The boxes mark the exons, including non-coding exons (orange) and coding exons (green). blue lines mark the introns. Start and stop codons are indicated. The numbers below the genes indicate the sizes of the exons and introns. b The structures of IRF family proteins. DBD represents the DNA-binding ___domain, LK represents the linker region, IAD represents interferon association ___domain, and AR represents auto-inhibitory region. Active domains (AD) are also marked on the figure. The upper numbers refer to the starting amino acid sites of diferent domains, and the different post-translational modifications of the IRFs are presented, including Phosphorylation, Ubiquitylation, SUMOylation, Methylation, and Acetylation
