Fig. 10
From: The multiple roles of interferon regulatory factor family in health and disease
The potential role of IRFs in metabolic and other diseases. a The roles of IRFs in metabolic diseases. b The roles of IRFs in other diseases. In brief, IRF1, IRF2, IRF5, and IRF7 present negative roles in these diseases. IRF3, IRF4, and IRF8 play protective roles, negative roles, or dual roles in these diseases. IRF6 is protective in non-alcoholic fatty liver disease, while a negative factor in kidney injury. IRF9 plays negative role in acute coronary syndrome and myocardial ischemia reperfusion, and kidney injury, while IRF9 plays protective role in obesity and diabetes
