Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity

Fig. 6

The prognosis value of the AHR-PD-L1-Tregs axis in breast cancer patients. a Representative immunofluorescent images showing F4/80 and AHR staining in the lungs of patients and control. Scale bars, 60 µm. The bar graph shows the percentage of AHR⁺ F4/80⁺ cells among AHR⁺ cells (n ≥ 35 for each group). b Overall survival of breast cancer patients with high and low AHR expression. c Overall survival of TNBC patients with high and low AHR expression. AHR expression and breast cancer patient survival analysis using the Kaplan-Meier Plotter online tool (http://kmplot.com/analysis/). d The correlation between AHR and PD-L1 (CD274) expression in breast cancer and its subtype, basal-like breast cancer. e The correlation between Treg cell infiltration and PD-L1 expression in breast cancer. f The correlation between Treg cell infiltration and AHR expression in breast cancer. The correlation analysis among AHR, PD-L1, and Treg cells was analyzed using the TIMER2.0 online tool (http://timer.cistrome.org/). Data are analyzed by unpaired two-tailed t-test (a) and presented as mean ± SEM. *p < 0.05

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