Fig. 5: Association enrichment in systolic blood pressure genes. | The Pharmacogenomics Journal

Fig. 5: Association enrichment in systolic blood pressure genes.

From: Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry

Fig. 5

The four plots show the distribution of the number of SNP associations with a p value lower than 1e−3, when randomly selecting 165 genome regions (1000 permutations) for the four different population groups (the whole cohort in black, European Americans in green, African Americans in red, Hispanic/Latinos in blue). The vertical bars correspond to the number of genes out of the 165 genes identified in the UKBB cohort to be associated with systolic blood pressure which obtain a p value lower than 1e−3 when looking for association with Δ SBP in our four cohorts. The 165 systolic blood pressure genes are nominally enriched in association with Δ SBP in European Americans (p value = 0.096), Hispanic/Latinos (p value = 0.069), African Americans (p value = 0.060), and in the whole cohort (p value = 0.083).

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