Table 1 Baseline characteristics of treatment naive AML/MDS patients(n = 54).

From: Plasma concentrations of venetoclax and Pharmacogenetics correlated with drug efficacy in treatment naive leukemia patients: a retrospective study

Clinical Characteristics

Mean ± standard deviation or number

Age (years)

64.5 ± 8.1

Gender (male/female)

31/23

Weight (kg)

57.0 ± 10.2

Risk stratified (good/moderate/poor/unknown)

6/13/28/7

Indication

 Acute myeloid leukemia

50

 Myelodysplastic syndrome (MDS)

4

Chemotherapy regimens

 Venetoclax and azacitidine (VA)

31

 VA based chemotherapy

7

 Venetoclax and other chemotherapeutic agents

16

Comorbidity

 Neutropenia

50

 Anemia

47

 Thrombocytopenia

46

 Pulmonary infection

37

 Hypokalemia

24

 Hypoproteinemia

18

 Pleural effusion

19

 Fungal Infection

13

 Pericardial effusion

10

 Liver Insufficiency

9

 Gallbladder stones

8

 Hyponatremia

6

Combination of drugs

 Voriconazole

16

 Posaconazole

9

Response

 Complete remission

28

 Partial remission

12

 Non-remission

14

Biochemical tests

 Platelet count (×109/L)

62.86 ± 91.55

 Neutrophils (×109/L)

0.42 ± 0.77

 White blood cell count (×109/L)

1.59 ± 2.08

 Hemoglobin (g/L)

68.28 ± 13.03

 Creatinine (μmol/L)

68.72 ± 22.39

 Alanine aminotransferase (U/L)

22.28 ± 17.21

 Aspartate Aminotransferase (U/L)

24.64 ± 31.23

 Albumin (g/dL)

33.73 ± 5.93

 Total bilirubin (mg/dL)

19.15 ± 16.98

  1. The risk stratified and response were assessed according to the 2022 European Leukemia Network criteria.