Fig. 5: Enrichment of MAPT p.R406W dysregulated genes in genetic risk for FTD. | Translational Psychiatry

Fig. 5: Enrichment of MAPT p.R406W dysregulated genes in genetic risk for FTD.

From: Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

Fig. 5

To determine whether the 61 verified differentially expressed genes in MAPT p.R406W carriers were enriched for FTD risk, i-GSEA4GWAS was employed for enrichment analysis of FTD risk. a Gene-based Manhattan plot of the enrichment analysis of the genetic association signals from FTD summary statistics for the 61 verified differentially expressed genes. b Comparative QQ plot of the genetic association signals from FTD summary statistics between all genes and the 61 verified differentially expressed genes

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