Table 1 Linear mixed model of association with the cognitive composite score (cog-comp).
From: Effects of polygenic risk for Alzheimer’s disease on rate of cognitive decline in normal aging
Estimate | SE | t | p | ||
|---|---|---|---|---|---|
(Intercept) | 2.622e − 01 | 7.640e − 02 | 3.432 | 0.000621 | *** |
Age at inclusion | −5.646e − 01 | 2.354e − 02 | −23.988 | 2.00E − 16 | *** |
Time | −1.952e − 02 | 2.497e − 03 | −7.815 | 7.82e − 15 | *** |
Age2 | −1.496e − 01 | 2.427e − 02 | −6.167 | 9.58e − 10 | *** |
Sex | −7.792e − 02 | 4.534e − 02 | −1.718 | 0.085975 | . |
C1 | 9.926e − 02 | 2.283e − 02 | 4.347 | 1.50e − 05 | *** |
C2 | 4.810e − 02 | 2.308e − 02 | 2.084 | 0.037368 | * |
C3 | 8.159e − 02 | 2.298e − 02 | 3.551 | 0.000399 | *** |
C6 | −4.455e − 02 | 2.292e − 02 | −1.944 | 0.052108 | . |
APOE ɛ4 | −9.845e − 03 | 5.150e − 02 | −0.191 | 0.848433 | |
PGS-COG | 1.677e − 01 | 2.303e − 02 | 7.283 | 6.04e − 13 | *** |
PRS-LOAD | −1.968e − 02 | 2.312e − 02 | −0.851 | 0.394875 | |
Time × age | −1.626e − 02 | 1.205e − 03 | −13.495 | 2.00E − 16 | *** |
Time × age inclusion2 | 2.185e − 03 | 1.063e − 03 | 2.056 | 0.039828 | * |
Time × sex | −2.898e − 03 | 1.503e − 03 | −1.928 | 0.053918 | . |
Time × C1 | 7.254e − 04 | 7.440e − 04 | 0.975 | 0.329656 | |
Time × C2 | 8.406e − 04 | 7.402e − 04 | 1.136 | 0.256244 | |
Time × C3 | −1.020e − 03 | 7.617e − 04 | −1.339 | 0.180840 | |
Time*C6 | 1.003e − 03 | 7.673e − 04 | 1.307 | 0.191263 | |
Time × APOE ɛ4 | −3.394e − 03 | 1.677e − 03 | −2.024 | 0.043062 | * |
Time × PGS-COG | −3.240e − 04 | 7.858e − 04 | −0.412 | 0.680098 | |
Time × PRS-LOAD | −1.811e − 03 | 7.642e − 04 | −2.370 | 0.017839 | * |
