Fig. 1: Boxplots of PRS and pPRS in the different settings.
a (above) shows the PRS including all the 29 known AD-associated variants, with and without APOE variants. As weight for the PRS, we used published variant effect-sizes (Supplementary Table S1). b (central) and c (bottom) show the pPRS for each of the selected molecular pathways, including and excluding APOE variants, respectively. For all plots, risk scores were calculated for AD cases, population subjects, and cognitively healthy centenarians. Then, risk scores were compared between (i) AD cases and population subjects (A vs. P comparison) and (ii) cognitively healthy centenarians and population subjects (C vs. P comparison). For representation, we scaled all PRS and pathway-PRS to be mean = 0 and SD = 1. For the comparison, we used logistic regression models with risk scores as predictors. Annotation: ***p-value of association < 5 × 10−6; **p-value of association < 5 × 10−4; *p-value of association < 5 × 10−2.
