Table 3 Summary results when meta-analyses performed in case–control studies are united with those performed in transmission disequilibrium test (TDT) for each allele of the 48 bp VNTR in DRD4 gene.
Case/trasmitted | Control/untrasmitted | ||||||
|---|---|---|---|---|---|---|---|
Allele | Events | Total events | Events | Total events | Odd ratio, M-H, Random, 95% CI | Heterogeneity | Test for overall effect |
2 | |||||||
Asian | 563 | 3481 | 609 | 3523 | 0.98 [0.81, 1.19] | Tau² = 0.07; Chi² = 29.16, df = 16 (P = 0.02); I² = 45% | Z = 0.23 (P = 0.82) |
European-Caucasian | 508 | 5256 | 798 | 7983 | 0.98 [0.84, 1.14] | Tau² = 0.04; Chi² = 35.69, df = 26 (P = 0.10); I² = 27% | Z = 0.29 (P = 0.77) |
Middle Eastern | 62 | 682 | 39 | 684 | 1.60 [0.45, 5.73] | Tau² = 1.81; Chi² = 24.56, df = 5 (P = 0.0002); I² = 80% | Z = 0.72 (P = 0.47) |
South American | 100 | 1310 | 516 | 6578 | 1.18 [0.79, 1.78] | Tau² = 0.08; Chi² = 6.36, df = 4 (P = 0.17); I² = 37% | Z = 0.80 (P = 0.42) |
4 | |||||||
Asian | 2773 | 3582 | 2693 | 3624 | 1.25 [0.95, 1.64] | Tau² = 0.26; Chi² = 83.77, df = 17 (P < 0.00001); I² = 80% | Z = 1.59 (P = 0.11) |
European-Caucasian | 3163 | 5256 | 5250 | 7983 | 0.83 [0.74, 0.94] | Tau² = 0.05; Chi² = 54.33, df = 26 (P = 0.0009); I² = 52% | Z = 3.08 (P = 0.002) |
Middle Eastern | 460 | 750 | 433 | 784 | 1.15 [0.57, 2.33] | Tau² = 0.68; Chi² = 39.64, df = 6 (P < 0.00001); I² = 85% | Z = 0.39 (P = 0.69) |
South American | 889 | 1482 | 4189 | 6692 | 0.83 [0.67, 1.03] | Tau² = 0.03; Chi² = 10.02, df = 6 (P = 0.12); I² = 40% | Z = 1.69 (P = 0.09) |
European-Caucasian and South American | 4052 | 6738 | 9439 | 14,675 | 0.83 [0.75, 0.92] | Tau² = 0.04; Chi² = 64.55, df = 33 (P = 0.0008); I² = 49% | Z = 3.58 (P = 0.0003) |
7 | |||||||
Asian | 18 | 2054 | 22 | 2441 | 0.93 [0.48, 1.80] | Tau² = 0.00; Chi² = 6.18, df = 11 (P = 0.86); I² = 0% | Z = 0.22 (P = 0.82) |
European-Caucasian | 2936 | 10,820 | 4999 | 19,707 | 1.31 [1.17, 1.47] | Tau² = 0.09; Chi² = 138.89, df = 47 (P < 0.00001); I² = 66% | Z = 4.70 (P < 0.00001) |
European-Caucasian without Sonuga-Barke et al.47 | 2476 | 9416 | 4475 | 18,319 | 1.33 [1.19, 1.49] | Tau² = 0.08; Chi² = 111.59, df = 46 (P < 0.00001); I² = 59% | Z = 5.13 (P < 0.00001) |
European-Caucasian without Sonuga-Barke et al.47 and Altink et al.48 | 2276 | 8776 | 4333 | 17,963 | 1.36 [1.22, 1.50] | Tau² = 0.06; Chi² = 90.82, df = 45 (P < 0.0001); I² = 50% | Z = 5.82 (P < 0.00001) |
Middle Eastern | 127 | 1150 | 152 | 982 | 0.73 [0.50, 1.06] | Tau² = 0.11; Chi² = 12.02, df = 7 (P = 0.10); I² = 42% | Z = 1.65 (P = 0.10) |
South American | 452 | 1803 | 1379 | 7009 | 1.18 [0.95, 1.47] | Tau² = 0.04; Chi² = 15.15, df = 9 (P = 0.09); I² = 41% | Z = 1.53 (P = 0.13) |
Long | |||||||
Asian | 104 | 3631 | 81 | 3593 | 1.27 [0.89, 1.82] | Tau² = 0.05; Chi² = 17.74, df = 16 (P = 0.34); I² = 10% | Z = 1.33 (P = 0.18) |
European-Caucasian | 1379 | 5429 | 1520 | 8175 | 1.36 [1.20, 1.55] | Tau² = 0.05; Chi² = 51.33, df = 27 (P = 0.003); I² = 47% | Z = 4.78 (P < 0.00001) |
Middle Eastern | 197 | 1157 | 605 | 2767 | 0.61 [0.42, 0.88] | Tau² = 0.16; Chi² = 18.70, df = 7 (P = 0.009); I² = 63% | Z = 2.61 (P = 0.009) |
South American | 306 | 1213 | 1276 | 5920 | 1.13 [0.93, 1.38] | Tau² = 0.01; Chi² = 4.90, df = 4 (P = 0.30); I² = 18% | Z = 1.23 (P = 0.22) |
