Fig. 4: Brain organoids differentially recapitulated the timing of corticogenesis.
From: Benchmarking brain organoid recapitulation of fetal corticogenesis
A Schematic representation of in-house and external BO datasets and relative differentiation time points (CBO cortical brain organoids, FO forebrain organoids, TA telencephalic aggregates, MGO minimally-guided neural organoids). B Stage-wise differential expression analysis in MGO, FO, and TA. Barplots reporting the number of DEGs (FDR < 0.05, log2FC > 1 as absolute value), shown as upregulated and downregulated genes for each comparison. C Boxplots reporting the fraction of Progenitors and Neurons estimated by bulk deconvolution in each organoid dataset. D Correlation analysis of organoid datasets against the BS fetal cortex. Heatmaps visualize the correlation coefficient (Spearman correlation) for each organoid data point and each BS PCW.
