Fig. 1: Distributions of correlation coefficients between cortical thickness difference and gene-expression. | Translational Psychiatry

Fig. 1: Distributions of correlation coefficients between cortical thickness difference and gene-expression.

From: Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure

Fig. 1

Distributions of the inter-regional correlation coefficients between differences in cortical thickness (CT) and profiles of gene-expression in adults (A) and adolescents (B). The CT-difference profiles were obtained from our LEAP data, and the expression profiles from the Allen Human Brian Atlas (AHBA), in our glutamate-pathway and GABA-pathway gene-sets. The x-axes show the correlation coefficient between CT-difference and expression profile for all genes in the gene-set; the y-axes show the estimated probability density for the correlation coefficients; the vertical dashed-lines indicates the average expression-CT difference correlation coefficient across all the marker genes in a gene-set; and the edges of the gray boxes indicates the 2.5% and 97.5%-critical values obtained from the empirical null distribution of the average expression-thickness correlation coefficient. If a vertical line sits outside the gray box, it implies that there is a significant association between gene-set and differences in CT at the unadjusted 5% significance level.

Back to article page