Fig. 3: Chronic administration of haloperidol increases inhibitory synaptic transmission onto both D2- and D1-MSNs. | Translational Psychiatry

Fig. 3: Chronic administration of haloperidol increases inhibitory synaptic transmission onto both D2- and D1-MSNs.

From: Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons

Fig. 3

A Illustration of the protocol used to record sIPSC. B, G Representative traces of sIPSC obtained from D2-MSNs and D1-MSNs, respectively. C, H Cumulative distribution of sIPSC inter-event intervals in vehicle (n = 15 cells) or haloperidol-treated (n = 20 cells) D2- and D1-MSNs, respectively. Inset shows average sIPSC frequency. D, I Cumulative distribution of sIPSC amplitudes in vehicle (n = 15 cells) or haloperidol-treated (n = 20 cells) D2- and D1-MSNs, respectively. Inset shows average sIPSC amplitude. E, J Average decay time of sIPSC recorded from D2- and D1-MSNs of vehicle (n = 15 cells) or haloperidol-treated (n = 20 cells) mice. F, K Average 10–90% rise time (RT) of sIPSC recorded from D2- and D1-MSNs of vehicle (n = 15 cells) or haloperidol-treated (n = 20 cells) mice. Welch’s unpaired t test for all panels except for cumulative distributions (Kolmogorov–Smirnov test for cumulatives). *p < 0.05, **p < 0.01, ****p < 0.0001. Statistical details are shown in Supplementary Table S2.

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