Fig. 5: Summary scheme of the results.
From: Disrupted basolateral amygdala circuits supports negative valence bias in depressive states
Depressive state in both BD patients and CORT-induced model for depression induce a negative olfactory bias (right) respect to healthy state (left). Patients present decreased number of odors rated as pleasant associated with increased number of rated unpleasant odors respect to control subject, while CORT-treated mice exhibit decreased approach behavior towards appetitive odors and increased avoidance behaviour towards aversive odors respect to control group. The chronic CORT administration elevates the activity of BLA projecting neurons to the CeA, which preferentially encode negative valence, and reduces the activity of BLA projecting neurons to the NAc, preferentially encoding positive valence.
