Fig. 1: Environmental and Genetic Interactions with Endophenotypes 1.0 and 2.0. | Translational Psychiatry

Fig. 1: Environmental and Genetic Interactions with Endophenotypes 1.0 and 2.0.

From: Endophenotype 2.0: updated definitions and criteria for endophenotypes of psychiatric disorders, incorporating new technologies and findings

Fig. 1

The Hypothesized path analysis may resolve the mechanistic causal relationships from genetic variations (G) and environmental factors (E) to major endophenotypes (both 1.0 and 2.0) and, ultimately, disorders. The effect of each edge could be quantified in future studies.

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