Fig. 4: Identification of NAc transcripts commonly regulated by voluntary heroin intake and LPS pretreatment. | Translational Psychiatry

Fig. 4: Identification of NAc transcripts commonly regulated by voluntary heroin intake and LPS pretreatment.

From: Neuroinflammatory history results in overlapping transcriptional signatures with heroin exposure in the nucleus accumbens and alters responsiveness to heroin in male rats

Fig. 4

A Volcano plot depicting differentially expressed genes (DEGs) in the NAc between Heroin self-administration (Heroin-SA) and saline-SA. Upregulated DEGs are represented in red, downregulated DEGs are represented in blue. Bar graphs representing GO BP (B) and KEGG (C) pathway analysis. Red bars represent significant pathways deriving from upregulated genes; blue bars represent significant pathways deriving from downregulated genes. Venn diagrams of total differential expressed genes (DEGs) regulated by LPS-Saline and/or Heroin-SA (D); Saline-Heroin and/or Heroin-SA (E); or LPS-Heroin and/or Heroin-SA (F) in the NAc. Red numbers represent genes co-regulated in both groups; the asterisk (*) represent a p < 0.0001 obtained with the Fisher exact test. RRHO plots comparing the NAc transcriptome between LPS-Saline and Heroin-SA (G); Saline-Heroin and Heroin-SA (H); or LPS-Heroin and Heroin-SA (I). White arrows represent gene expression directionality. Upper right quadrant represents genes down-regulated in both groups while lower left quadrant represents genes up-regulated in both groups. J Venn diagram of DEGs regulated by LPS-Saline, Saline-Heroin, LPS-Heroin and Heroin-SA in the NAc. Red numbers represent genes co-regulated in both groups. K Table of the 22 co-regulated genes from (J). Bar graphs representing KEGG (L) and GO BP (M) pathway analysis of the 22 co-regulated genes from (J).

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