Fig. 7: Inhibition of SARS-CoV-2 by H69C2 in Vero E6 cells.
From: Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
Vero E6 cells infected with SARS-CoV-2 at an MOI of 0.01 were treated with various concentrations of H69C2. (a) Quantitative RT-PCR assays were performed to measure the viral copy number in the cellular supernatant. The y-axis indicates percentage inhibition of the virus relative to the sample treated with DMSO (vehicle). (b) Cell viability assay. The y-axis represents the percentage of cell viability relative to the sample treated with DMSO (vehicle). (c) Immunofluorescence images of intracellular NP. At 24 h post-infection, cells were fixed, and intracellular NP levels were monitored by immunofluorescence. Scale bars, 400 μm. Data are shown as the mean ± s.e.m., n = 3.
