Table 1 Predicted ADMET properties of identified natural products.
From: Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
ADMET properties | H69C2 | H69D1 | MCCS-B | CDCP | GTCP |
|---|---|---|---|---|---|
Human intestinal absorption | + | + | − | + | − |
Blood–brain barrier | − | − | + | − | − |
P-glycoprotein substrate and inhibition | +− | −− | −− | −− | −− |
CYPs substrate and inhibition | +−−−−− | +−−−−− | +−−−−− | −−−−−− | +−−−−− |
Ames mutagenesis | + | − | − | − | + |
Hepatotoxicity | + | + | − | + | − |
