Fig. 6: The role of GHS-R1a/D2R heterodimers activation in dopaminergic neurons. | Acta Pharmacologica Sinica

Fig. 6: The role of GHS-R1a/D2R heterodimers activation in dopaminergic neurons.

From: Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson’s disease mouse model through activating GHS-R1a/D2R heterodimers

Fig. 6

GHS-R1a and D2R receptors form heterodimers in dopaminergic neurons, GHS-R1a/D2R heterodimers activation upregulates TH expression through CaM-mediated CREB signaling pathway, promotes synthesis and release of DA, and antagonizes MPTP-induced behavioral changes in WT mice.

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