Fig. 4: Analysis of immunoglobulin transcripts in B-NHLs.
From: Combining gene expression profiling and machine learning to diagnose B-cell non-Hodgkin lymphoma
a Schematic of the regulation of immunoglobulin transcripts. Mature B-cells constitutively transcribe VDJ, Cµ, and Cδ encoding IgM and IgD. In the presence of specific sets of activation signals, B-cells initiate class switch recombination through the germline transcription of downstream Cγ, Cα or Cε genes. The expression of sterile transcripts required for class switching after AICDA-induced genetic instability is also displayed for different subtypes. b Differential expression of the immunoglobulin transcripts IGHM and IGHD and the expression of AICDA in the global cohort are plotted, showing an overexpression of IGHM in tumor cells from patients with SLL, MZL, MCL, and ABC DLBCL. c Differential expression of immunoglobulin sterile transcripts required for class switching are plotted, showing a high expression of Iµ-Cµ transcript in IGHM-positive tumors, for except ABC DLBCL, despite AICDA expression. The sterile transcript Iε-Cε is consistently and almost exclusively expressed in FL samples.
