Fig. 6: Multiplex immunofluorescence demonstrates infiltration by CD8⁺ RORγT⁺ T cells in GI biopsies from patients with high toxicity.

A RORγT⁺ cells measured by cell density or % of total T cells, comparing patients with high GI toxicity to low/no toxicity. Infiltration is seen in both stroma and epithelium. B CD8⁺ RORγT⁺ infiltration in patients with high GI toxicity, seen in both stroma and epithelium. C FOXP3⁺ cells measured by % of total T cells or cell density, between patients with high GI toxicity or low/no toxicity. D CD4⁺ FOXP3⁺ cells measured by cell density between epithelium and stroma regions. A–D Patients with a liver biopsy are excluded from these graphs. ns = not significant; *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.