Fig. 1: U2AF1 mutation structure and somatic co-mutation pattern. | Blood Cancer Journal

Fig. 1: U2AF1 mutation structure and somatic co-mutation pattern.

From: U2AF1 pathogenic variants in myeloid neoplasms and precursor states: distribution of co-mutations and prognostic heterogeneity

Fig. 1

a Overview of U2AF1 domains, structures, and distribution of U2AF1 mutations detected, positioned on the U2AF1 protein. Protein Sequence of ZF1 (hotspots at codon 34; S34F and S34Y) and ZF2 (hotspots at codon 157; Q157R and Q157P) domains, where all U2AF1 mutations clustered. b Patterns of the co-mutations identified in the U2AF1 cohort with respective mutations. NTD N-terminal ___domain, ZF zinc finger ___domain, RRM RNA recognition motifs, RS The C-terminal Arg-Ser rich ___domain, CTD C-terminal ___domain.

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