Fig. 6: TCR clonotype abundance, gene expression, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. | Blood Cancer Journal

Fig. 6: TCR clonotype abundance, gene expression, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment.

From: Bispecific CAR-T cells targeting CD19/20 in patients with relapsed or refractory B cell non-Hodgkin lymphoma: a phase I/II trial

Fig. 6

A Stacked bar plot represents the abundance of the first 9 top TCR clonotypes of CAR-T cells from infusion product (IP) and peripheral blood (PB) on day 21 after infusion. B The volcano plot of significantly changed genes in the top 3 TCR clonotypes vs. other TCR clonotypes of CAR-T cells from IP. The criteria for identifying differentially expressed genes (DEGs) with significant differences using a volcano plot are as follows: the absolute value of the log2 fold-change (|log2FC | ) must be equal to or greater than 1, and the adjusted p-value (based on Bonferroni correction using all features in the dataset) must be less than 10e-06. The DEGs were up-regulated or down-regulated according to the log2FC value > 1 or < − 1. C Top KEGG terms enriched in upregulated genes in 3 top clonotypes compared to other clones in CAR-T cell from IP. Fisher’s exact test. KEGG Kyoto Encyclopedia of Genes and Genomes.

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