Fig. 6: Upregulation of b-catenin reverses osteopenia in Kind2-D1 mice.
From: Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice
a Three-dimensional (3D) reconstruction from microcomputerized tomography (mCT) scans of distal femurs from 43-d-old male Kind2-D1 mice and their control littermates. b–g Quantitative analyses of bone volume/tissue volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), cortical thickness (Cort.Th), and bone mineral density (BMD) of distal femurs from Kind2-D1 mice and control littermates. N = 6 mice in the Kind2-D1 group and N = 5 mice in the control, b-cat(∆ex3), and Kind2-D1; b-cat (∆ex) groups, Student’s t-test. The results are expressed as the mean ± standard deviation (s.d.). *P < 0.05, **P < 0.01, versus controls, Student’s t-test. The results are expressed as the mean ± s.d.
