Fig. 4
From: Inhibition of immune checkpoints prevents injury-induced heterotopic ossification
Loss of function of inhibitory ICs blocks HO, while loss of function of stimulatory ICs facilitates HO. a, b Neutralizing antibodies against stimulatory ICs (CD40 and CD134) facilitated HO formation (n = 3) *P < 0.05 vs control group. c, d Neutralizing antibody against inhibitory ICs (PD1, PD-L1, and CD152) almost completely inhibited HO formation (n = 3), *P < 0.05 vs control group
