Fig. 1 | Bone Research

Fig. 1

From: Type II collagen-positive progenitors are important stem cells in controlling skeletal development and vascular formation

Fig. 1

Spatial expression of Col2+ lineage progenitors in newborns and removal of the majority of Col2+ cells by DTA. a Fluorescence images showing the pattern of Col2+ lineage progenitors in middle sections of Col2-cre;tdTomato and Col2-cre;DTA+/−;tdTomato newborn mice. b Fluorescence images showing the pattern of Col2+ lineage progenitors in transected skulls of Col2-cre;tdTomato and Col2-cre;DTA+/−;tdTomato mice. White arrow, defective nasal capsule in a Col2-cre;DTA+/−;tdTomato mouse. c Fluorescence images showing the pattern of Col2+ lineage progenitors in the lower extremities of Col2-cre;tdTomato and Col2-cre;DTA+/−;tdTomato newborn mice. Note the complete loss of tdTomato+ cells in the long bones of Col2-cre;DTA+/−;tdTomato mice compared with wild-type newborn mice. d Fluorescence images showing the pattern of Col2+ lineage progenitors in middle sagittal sections of spines of Col2-cre;tdTomato and Col2-cre;DTA+/−;tdTomato newborn mice. n = 6 mice per condition; three independent experiments

Back to article page