Table 2 Exosomal miRNAs implicated in RA

From: Comprehensive overview of microRNA function in rheumatoid arthritis

Cellular origin

Encapsulated miRNAs

Recipient cell(s)

Target(s)

Function(s)

Ref.

FLSs

MiR-221-3p

Osteoblasts

DKK2

↓Osteogenesis

198

FLSs

MiR-486-5p

Osteoblasts

TOB1

↑Osteogenesis

221

FLSs

MiR-106b

Chondrocytes

PDK4

↓Chondrocyte proliferation and migration

↑ Chondrocyte apoptosis

222

FLSs

MiR-424

Th17 cells

Tregs

FOXP3

↑Th17 cell differentiation

↓ Treg differentiation

223

MSCs

MiR-320a

FLSs

CXCL9

↓Activation, migration, and invasion of RA-FLSs

224

MSCs

MiR-150-5p

FLSs

HUVECs

MMP14, VEGF

↓Synovial hyperplasia

↓ Angiogenesis

225

MSCs

MiR-124a

FLSs

ND

↓Proliferation and migration of RA-FLSs

↑ Apoptosis of RA-FLSs

226

MSCs

MiR-140-3p

FLSs

Chondrocytes

SGK1

↓Proliferation and migration of RA-FLSs

↑ Apoptosis of RA-FLSs

↓ Chondrocyte apoptosis

227

MSCs

MiR-146a

MiR-155

Tregs

FOXP3, TGF-β, IL-10, RORγt, IL-17, IL-6

↑ Proportion of Tregs

228

T cells

MiR-204-5p

FLSs

CRKL, ANGPT1, TGFβR1, TGFβR2

↓ Activation, proliferation, invasion, and inflammatory cytokine production of RA-FLSs

229

Th17 cells

MiR-132

Osteoclasts

COX2

↑Osteoclastogenesis

188

  1. miRNA microRNA, RA rheumatoid arthritis, FLS fibroblast-like synoviocyte, MSC mesenchymal stem cell, ND not determined