Table 2 Exosomal miRNAs implicated in RA
From: Comprehensive overview of microRNA function in rheumatoid arthritis
Cellular origin | Encapsulated miRNAs | Recipient cell(s) | Target(s) | Function(s) | Ref. |
---|---|---|---|---|---|
FLSs | MiR-221-3p | Osteoblasts | DKK2 | ↓Osteogenesis | |
FLSs | MiR-486-5p | Osteoblasts | TOB1 | ↑Osteogenesis | |
FLSs | MiR-106b | Chondrocytes | PDK4 | ↓Chondrocyte proliferation and migration ↑ Chondrocyte apoptosis | |
FLSs | MiR-424 | Th17 cells Tregs | FOXP3 | ↑Th17 cell differentiation ↓ Treg differentiation | |
MSCs | MiR-320a | FLSs | CXCL9 | ↓Activation, migration, and invasion of RA-FLSs | |
MSCs | MiR-150-5p | FLSs HUVECs | MMP14, VEGF | ↓Synovial hyperplasia ↓ Angiogenesis | |
MSCs | MiR-124a | FLSs | ND | ↓Proliferation and migration of RA-FLSs ↑ Apoptosis of RA-FLSs | |
MSCs | MiR-140-3p | FLSs Chondrocytes | SGK1 | ↓Proliferation and migration of RA-FLSs ↑ Apoptosis of RA-FLSs ↓ Chondrocyte apoptosis | |
MSCs | MiR-146a MiR-155 | Tregs | FOXP3, TGF-β, IL-10, RORγt, IL-17, IL-6 | ↑ Proportion of Tregs | |
T cells | MiR-204-5p | FLSs | CRKL, ANGPT1, TGFβR1, TGFβR2 | ↓ Activation, proliferation, invasion, and inflammatory cytokine production of RA-FLSs | |
Th17 cells | MiR-132 | Osteoclasts | COX2 | ↑Osteoclastogenesis |