Fig. 2 | Bone Research

Fig. 2

From: Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease (GCKD) cohort

Fig. 2

Risk of outcomes for Q5 vs. Q1 biomarker levels in a cohort of n = 4 246 patients enrolled in the German Chronic Kidney Disease Study (GCKD) in Model 3. The evaluated biomarkers OPG, FGF23, iPTH, BAP, CTX1, phosphate, calcium, and 25-OH Vitamin D were statistically associated with selected outcomes, including (a) non-CV death, (b) CV death, (c) MACE, and (d) CHF. Data of Model 3, which adjusted for demographic characteristics of the study population and for biomarker levels other than the analyzed one. CV cardiovascular, HR hazard ratio, CI confidence interval, MACE major adverse cardiac event, CHF hospitalization due to congestive heart failure, OPG osteoprotegerin, FGF23 fibroblast growth factor-23, iPTH intact parathyroid hormone, BAP bone alkaline phosphatase, CTX1 cross-linked C-telopeptide of type I collagen, P1NP procollagen I intact N-terminal

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