Fig. 3 | Bone Research

Fig. 3

From: Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways

Fig. 3

Hand OA-related alteration of proportion in subpopulations and their potential function. a Differential analysis of subpopulation abundance between hand osteoarthritic and nonosteoarthritic cartilage. The Wilcoxon matched-pairs signed rank test was used for analysis, and a P value < 0.05 was considered significant. b GO enrichment analysis of DEGs from each chondrocyte subpopulation, showing distinct potential functions in hand articular cartilage tissue. c and d Heatmap and radar map showing the performance of 7 matrisome gene sets among each chondrocyte subpopulation. e and f Heatmap and radar map showing evident changes in matrisome genes in FC and CPC between hand osteoarthritic and nonosteoarthritic status. OA osteoarthritis, EC effector chondrocytes, preHTC prehypertrophic chondrocytes, RegC regulatory chondrocytes, preFC prefibrocartilage chondrocytes, FC fibrocartilage chondrocytes, HTC hypertrophic chondrocytes, InflamC inflammatory chondrocytes, MTC mitochondrial chondrocytes, HomC homeostatic chondrocytes, CPC cartilage progenitor cells, DEGs differentially expressed genes, ECM extracellular matrix

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