Fig. 5 | British Journal of Cancer

Fig. 5

From: Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma

Fig. 5

MPM cells with low ER stress/UPR signalling are intrinsically resistant to chemotherapy. a, b Viability (a) and IC50 (b) of MPM lines and normal mesothelial cells (Met-5A) after treatment with bortezomib for 72 h. Data are presented as mean ± s.d. (n = 3). c Clonogenic assay of MESO-4 and BE261T cells treated with the indicated doses of bortezomib. d Immunoblots of MESO-4 and BE261T cells for proteins involved in the UPR and apoptosis. e Viability of MESO-4 and BE261T cells after treated with cisplatin/MTA for 72 h

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